Therapeutic Effect of Bleomycin Intralesional Injection on Keloids & Hypertrophic Scars.
- Author:
Sang Young PARK
1
;
Seong Eon KIM
;
Tae Jin YOON
Author Information
1. Department of Dermatology, School of Medicine, Gyeongsang National University, Jinju, Korea.
- Publication Type:Original Article
- Keywords:
Bleomycin;
Hypertrophic scar;
Intralesional injection;
Keloid
- MeSH:
Bleomycin;
Cicatrix;
Cicatrix, Hypertrophic;
Collagen;
Cosmetics;
Erythema;
Follow-Up Studies;
Humans;
Hyperpigmentation;
Hypopigmentation;
Injections, Intralesional;
Keloid;
Pliability;
Pruritus;
Self-Assessment;
Skin
- From:Korean Journal of Dermatology
2008;46(5):604-610
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Keloids and hypertrophic scars are benign growths of dermal collagen that usually cause major physical, psychological, and cosmetic problems. Numerous treatment modalities have been used to treat keloids and hypertrophic scars, but the optimal treatment has not been established. OBJECTIVE: The purpose of this study is to investigate whether bleomycin intralesional injection has an therapeutic effect on both keloids and hypertrophic scars. METHODS: Thirteen patients with keloids or hypertrophic scars were administered with intralesional injection of bleomycin (1.5 IU/ml). Scar height was measured, and scar pliability and erythema were scored at baseline and then monthly during the treatment and follow-up period. Patient's self-assessments of subjective symptoms (pruritus and pain) were also scored. Pre- and post-treatment mean values for scar height, scar pliability, erythema, pruritus and pain were statistically compared. RESULTS: The clinical response was positive in all cases: highly significant flattening in one case, significant flattening in one case, moderate flattening in five cases and minimal flattening in six cases. The mean scores for pruritus and pain also improved. The observed side-effects were hyperpigmentation (two cases), hypopigmentation (one case) and skin infection (one case). No exacerbation was noted during follow-up period of 4 months. CONCLUSION: Bleomycin intralesional injecton may be one of the effective and safe method of treating keloids and hypertrophic scars.
