A Case of Leukocytoclastic Vasculitis after Use of Sorafenib (Nexavar(R)).
- Author:
Hak Ju KIM
1
;
Ji Hye KIM
;
June Bum KIM
;
Hye Kyoung KIM
;
Yoo Soo KO
;
Ok Ja JOH
;
Jae Seung LEE
;
Kye Yong SONG
Author Information
1. Department of Dermatology, Seoul Veterans Hospital, Seoul, Korea. mdoct@freechal.com
- Publication Type:Case Report
- Keywords:
Leukocytoclastic vasculitis;
Nexavar(R);
Sorafenib
- MeSH:
Alopecia;
Angiogenesis Inducing Agents;
Carcinoma, Renal Cell;
Erythema;
Extremities;
Hand-Foot Syndrome;
Hemorrhage;
Kidney Neoplasms;
Niacinamide;
Phenylurea Compounds;
Phosphotransferases;
Scalp;
Tyrosine;
Vasculitis;
Vasculitis, Leukocytoclastic, Cutaneous
- From:Korean Journal of Dermatology
2008;46(5):648-651
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Sorafenib (Nexavar(R)) is an oral multikinase inhibitor that was recently approved for use in metastatic renal cancer. It is currently undergoing investigation for the treatment of locally advanced renal cancer and in other tumor types. It has a broad spectrum of activity in treating multiple tyrosine kinases, including angiogenic factors VEGFR and PDGFR. Common cutaneous toxicities experienced with sorafenib include facial and scalp erythema, hand-foot syndrome, splinter hemorrhages, and alopecia. We report a case of a 57 year-old man diagnosed as renal cell carcinoma with distant metastaisis, who developed a leukocytoclastic vasculitis on the extremities after use of sorafenib.
