Long-term Results of Percutaneous Ethanol Injection for the Treatment of Hepatocellular Carcinoma in Korea.
- Author:
Yon Mi SUNG
1
;
Dongil CHOI
;
Hyo K LIM
;
Won Jae LEE
;
Seung Hoon KIM
;
Min Ju KIM
;
Seung Woon PAIK
;
Byung Chul YOO
;
Kwang Cheol KOH
;
Joon Hyoek LEE
;
Moon Seok CHOI
Author Information
- Publication Type:Original Article
- Keywords: Liver, neoplasms; Liver neoplasms, therapy; Alcohol ablation
- MeSH: Treatment Outcome; Survival Rate; Survival Analysis; Risk Factors; Risk Assessment/*methods; Prognosis; Middle Aged; Male; Longitudinal Studies; Liver Neoplasms/*drug therapy/*mortality; Korea/epidemiology; Injections, Subcutaneous; Incidence; Humans; Female; Ethanol/*administration & dosage; Disease-Free Survival; Carcinoma, Hepatocellular/*drug therapy/*mortality; Antineoplastic Agents/administration & dosage; Adult
- From:Korean Journal of Radiology 2006;7(3):187-192
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: To evaluate the long-term follow-up results of percutaneous ethanol injection (PEI) for the treatment of hepatocellular carcinoma (HCC) in Korea. MATERIALS AND METHODS: Sixty-eight nodular HCCs initially detected in 64 patients, were subjected to US-guided PEI as a first-line treatment. Long-term survival rates, local tumor progression rates, and complications were evaluated, as were the influences of tumor size and Child-Pugh class on these variables. RESULTS: No major complications occurred. The overall survival rates of the 64 patients at three and five years were 71% and 39%, and their cancer-free survival rates were 22% and 15%, respectively. The overall survival rate of patients with a small HCC (< or = 2 cm) was significantly higher (p = 0.014) than that of patients with a medium-sized HCC (< or = 2 cm). The overall survival rate of patients with Child-Pugh class A was significantly higher (p = 0.049) than that of patients with Child-Pugh class B. Of 59 cases with no residual tumor, local tumor progression was observed in ablation zones in 18, and this was not found to be significantly influenced by tumor size or Child-Pugh class. CONCLUSION: The results of our investigation of the long-term survival rates of PEI in HCC patients in Korea (a hepatitis B virus-endemic area) were consistent with those reported previously in hepatitis C endemic areas. Patients with a smaller tumor or a better liver function exhibited superior survival rates.
