Korean Medication Algorithm for Bipolar Disorder 2006(IV): Rapid Cycling.
- Author:
Duk In JON
1
;
Won Myong BAHK
;
Eun LEE
;
Bo Hyun YOON
;
Sang Keun CHUNG
;
Won KIM
;
Young Chul SHIN
;
Hyun Sang CHO
;
Jun Soo KWON
;
Jeong Seok SEO
;
Kyoo Seob HA
;
Kyung Joon MIN
Author Information
1. Department of Psychiatry, College of Medicine, Hallym University, Anyang, Korea.
- Publication Type:Original Article
- Keywords:
Bipolar disorder;
Rapid cycling;
Korean medication algorithm;
Revision
- MeSH:
Advisory Committees;
Antipsychotic Agents;
Bipolar Disorder*;
Carbamazepine;
Expert Testimony;
Lithium;
Psychiatry;
Publications;
Surveys and Questionnaires;
Valproic Acid
- From:Korean Journal of Psychopharmacology
2006;17(5):449-455
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The development of treatment guidelines has emerged as an important element so as to standardize treatment and to provide clinicians with algorithms. From the previous publication of Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP): rapid cycling in 2002, we revised that in 2006. METHODS: The questionnaire to survey the expert opinion of medication for rapid cycling was completed by the review committee consisting of 53 experienced Korean psychiatrists. It is composed of 7 questions, and each question includes various options. We classified the expert opinion to 3 categories based on the lowest category in which the confidence interval fell (6.5 < or = for first-line and 3.5< or = for second-line treatment). RESULTS: Generally, 'treatment of choice' for rapid cycling was not demonstrated. The first-line treatment is the combination of a mood stabilizer and an atypical antipsychotic. Combination of two mood stabilizers was preferred as next strategy. Divalproex and lithium were the first-line choice as mood stabilizer. Compared to the surveys in 2002, the preference for lamotrigine and atypical antipsychotics has increased while that of carbamazepine and antidepressant has decreased. CONCLUSION: With the result of the survey, the discussion in executive committee, and the evidences from clinical studies, we have revised KMAP-BP for rapid cycling.
