The Bipolar Diathesis in Patients with Treatment Resistant Depression.
- Author:
Young Sup WOO
1
;
Jeong Ho CHAE
;
Ho Jun SEO
;
Hoo Rim SONG
;
Tae Youn JUN
;
Kwang Soo KIM
;
Won Myong BAHK
Author Information
1. Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea. wmbahk@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Treatment resistant depression;
Bipolar diathesis;
Bipolar spectrum disorder
- MeSH:
Bipolar Disorder;
Depressive Disorder, Major;
Depressive Disorder, Treatment-Resistant*;
Diagnosis;
Diagnostic and Statistical Manual of Mental Disorders;
Disease Susceptibility*;
Follow-Up Studies;
Hospitalization;
Humans;
Medical Records;
Prevalence
- From:Korean Journal of Psychopharmacology
2006;17(5):456-460
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: In this study, we determined the prevalence of bipolarity in patients with treatment resistant depression (TRD) by investigating demographic and clinical characteristics, diagnostic subtypes, and illness outcome. METHOD: A medical record review of patients admitted to a university hospital with the diagnosis of major depressive disorder (MDD) was conducted. DSM-IV diagnoses at index hospitalization and six months after discharge and detailed clinical information were obtained. We categorized subjects into a TRD group or a non-TRD group and re-evaluated the patients using the recently proposed criteria for bipolar spectrum disorder (BSD). Patients in the TRD group were compared with patients in the non-TRD group with regard to the prevalence rate of BSD at the index hospitalization and at the end of the follow up period. RESULTS: There were 281 patients diagnosed as MDD. At discharge, the number of patients who fulfilled the criteria for BSD was higher (p<.001) in the TRD group (32/68, 47.1%) than in the non-TRD group (8/213, 3.8%). At the end of six-month follow-up period, the diagnoses of 38 patients changed ; 18 (26.5%) in the TRD group were subsequently classified as having bipolar disorder, and seven (3.3%) in the non-TRD group (p<0.001). There was no difference between these two groups in other clinical and demographic variables. CONCLUSION: The findings suggest that a large number of patients with TRD have a bipolar diathesis.
