Insulin-like growth factor (IGF)-I and IGF binding proteins axis in diabetes mellitus.
10.6065/apem.2015.20.2.69
- Author:
Min Sun KIM
1
;
Dae Yeol LEE
Author Information
1. Department of Pediatrics, Chonbuk National University Medical School, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Institute of Chonbuk National University Hospital, Jeonju, Korea. leedy@jbnu.ac.kr
- Publication Type:Review
- Keywords:
Diabetes mellitus;
Insulin-like growth factor I;
Insulin-like growth factor binding protein 1;
Insulin-like growth factor binding protein 3;
Lipid metabolism
- MeSH:
Axis*;
Carrier Proteins;
Diabetes Mellitus*;
Diabetes Mellitus, Type 1;
Glucose;
Glucose Intolerance;
Humans;
Insulin;
Insulin-Like Growth Factor Binding Protein 1;
Insulin-Like Growth Factor Binding Protein 3;
Insulin-Like Growth Factor Binding Proteins*;
Insulin-Like Growth Factor I;
Lipid Metabolism
- From:Annals of Pediatric Endocrinology & Metabolism
2015;20(2):69-73
- CountryRepublic of Korea
- Language:English
-
Abstract:
Increasing evidence suggests an important role of the insulin-like growth factor (IGF)-IGF binding protein (IGFBP) axis in the maintenance of normal glucose and lipid metabolism. Significant changes occur in the local IGF-I-IGFBPs environment in response to the diabetic milieu. A significant reduction of serum IGF-I levels was observed in patients with type 1 diabetes mellitus (T1DM). Inversely, considerably increased serum levels of IGF-I and IGFBP-3 levels were detected in individuals with glucose intolerance including T2DM. Recently, several prospective studies indicated that baseline levels of IGF-I and IGFBPs are associated with the development of diabetes. These findings suggest that disturbances in insulin and IGF-I-IGFBP axis can affect the development of glucose intolerance including diabetes.
