Primary Radiation Therapy of Polymorhic Reticulosis.
- Author:
Jae Sung KIM
1
;
Yong Chan AHN
;
Hyoung Geun YUN
;
Charn Il PARK
Author Information
1. Department of Therapeutic Radiology, Seoul National University, College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Polymorphic reticulosis;
Treatment volume;
Radiotherapy;
Dose
- MeSH:
Fever;
Follow-Up Studies;
Granuloma, Lethal Midline;
Humans;
Lymphoma, Large B-Cell, Diffuse;
Nasal Cavity;
Palate;
Radiotherapy;
Recurrence;
Survival Rate;
Sweat;
Weight Loss
- From:Journal of the Korean Society for Therapeutic Radiology
1991;9(1):111-116
- CountryRepublic of Korea
- Language:English
-
Abstract:
From 1979 to 1987, 33 patients with polymorphic retrculosis (PMR) limited in the upper airway were treated with primary radiation therapy and the analysis of treatment results was undertaken. Systemic symptoms such as fever, night sweats, and weight loss were noted in 48%. The nasal cavity was most frequently involved (85%), although involvement of PNS (33%) and palate (30%) was not uncommon. The 5 and 10 year actuarial survival rates were 47% and 40%, respectively. The difference in NSD between patients with in-field failure and those without it was significant statistically. Also, field size was significantly smaller in patients with marginal failure than those without it. During the follow-up period, systemic failure was found in 5 patients (diffuse histiocytic lymphoma in 4, histiocytic medullary retriculosis in 1). In this study, we can suggested that total radiation dose of at least 4500 cGy with generous treatment volume should be delivered to achieve better local control and that the development of an effective systemic chemotherapeutic regimen is required to improve the survival after systemic relapse.
