Dynamic Contrast-Enhanced MRI Using a Macromolecular MR Contrast Agent (P792): Evaluation of Antivascular Drug Effect in a Rabbit VX2 Liver Tumor Model.
10.3348/kjr.2015.16.5.1029
- Author:
Hee Sun PARK
1
;
Joon Koo HAN
;
Jeong Min LEE
;
Young Il KIM
;
Sungmin WOO
;
Jung Hwan YOON
;
Jin Young CHOI
;
Byung Ihn CHOI
Author Information
1. Department of Radiology, Konkuk University School of Medicine, Seoul 05030, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Magnetic resonance imaging;
Contrast agents;
Antitumor agents;
Animal experimentation;
Liver neoplasms
- MeSH:
Animals;
Antineoplastic Agents/therapeutic use;
Benzophenones/therapeutic use;
Disease Models, Animal;
Heterocyclic Compounds/administration & dosage/*chemistry;
Liver Neoplasms/drug therapy/pathology/*radiography;
*Magnetic Resonance Imaging;
Male;
Organometallic Compounds/administration & dosage/*chemistry;
Rabbits;
Reproducibility of Results;
Valine/analogs & derivatives/therapeutic use
- From:Korean Journal of Radiology
2015;16(5):1029-1037
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To evaluate the utility of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using macromolecular contrast agent (P792) for assessment of vascular disrupting drug effect in rabbit VX2 liver tumor models. MATERIALS AND METHODS: This study was approved by our Institutional Animal Care and Use Committee. DCE-MRI was performed with 3-T scanner in 13 VX2 liver tumor-bearing rabbits, before, 4 hours after, and 24 hours after administration of vascular disrupting agent (VDA), using gadomelitol (P792, n = 7) or low molecular weight contrast agent (gadoterate meglumine [Gd-DOTA], n = 6). P792 was injected at a of dose 0.05 mmol/kg, while that of Gd-DOTA was 0.2 mmol/kg. DCE-MRI parameters including volume transfer coefficient (K(trans)) and initial area under the gadolinium concentration-time curve until 60 seconds (iAUC) of tumors were compared between the 2 groups at each time point. DCE-MRI parameters were correlated with tumor histopathology. Reproducibility in measurement of DCE-MRI parameters and image quality of source MR were compared between groups. RESULTS: P792 group showed a more prominent decrease in K(trans) and iAUC at 4 hours and 24 hours, as compared to the Gd-DOTA group. Changes in DCE-MRI parameters showed a weak correlation with histologic parameters (necrotic fraction and microvessel density) in both groups. Reproducibility of DCE-MRI parameters and overall image quality was not significantly better in the P792 group, as compared to the Gd-DOTA group. CONCLUSION: Dynamic contrast-enhanced magnetic resonance imaging using a macromolecular contrast agent shows changes of hepatic perfusion more clearly after administration of the VDA. Gadolinium was required at smaller doses than a low molecular contrast agent.
