Relationship between Myocardial Extracellular Space Expansion Estimated with Post-Contrast T1 Mapping MRI and Left Ventricular Remodeling and Neurohormonal Activation in Patients with Dilated Cardiomyopathy.
10.3348/kjr.2015.16.5.1153
- Author:
Ji Hyun YOON
1
;
Jung Woo SON
;
Hyemoon CHUNG
;
Chul Hwan PARK
;
Young Jin KIM
;
Hyuk Jae CHANG
;
Geu Ru HONG
;
Tae Hoon KIM
;
Jong Won HA
;
Byoung Wook CHOI
;
Se Joong RIM
;
Namsik CHUNG
;
Eui Young CHOI
Author Information
1. Cardiology Division, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 06273, Korea. CHOI0928@yuhs.ac
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Dilated cardiomyopathy;
T1 mapping;
Diastolic function
- MeSH:
Adult;
Aged;
Algorithms;
Blood Pressure;
Cardiomyopathy, Dilated/*diagnosis/radiography;
Echocardiography;
Extracellular Space/physiology/*radiography;
Female;
Heart Ventricles/physiopathology/radiography;
Humans;
Magnetic Resonance Imaging;
Male;
Middle Aged;
Multivariate Analysis;
Natriuretic Peptide, Brain/analysis;
Peptide Fragments/analysis;
*Ventricular Remodeling
- From:Korean Journal of Radiology
2015;16(5):1153-1162
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Post-contrast T1 values are closely related to the degree of myocardial extracellular space expansion. We determined the relationship between post-contrast T1 values and left ventricular (LV) diastolic function, LV remodeling, and neurohormonal activation in patients with dilated cardiomyopathy (DCM). MATERIALS AND METHODS: Fifty-nine patients with DCM (mean age, 55 +/- 15 years; 41 males and 18 females) who underwent both 1.5T magnetic resonance imaging and echocardiography were enrolled. The post-contrast 10-minute T1 value was generated from inversion time scout images obtained using the Look-Locker inversion recovery sequence and a curve-fitting algorithm. The T1 sample volume was obtained from three interventricular septal points, and the mean T1 value was used for analysis. The N-Terminal pro-B-type natriuretic peptide (NT-proBNP) level was measured in 40 patients. RESULTS: The mean LV ejection fraction was 24 +/- 9% and the post-T1 value was 254.5 +/- 46.4 ms. The post-contrast T1 value was significantly correlated with systolic longitudinal septal velocity (s'), peak late diastolic velocity of the mitral annulus (a'), the diastolic elastance index (Ed, [E/e']/stroke volume), LV mass/volume ratio, LV end-diastolic wall stress, and LV end-systolic wall stress. In a multivariate analysis without NT-proBNP, T1 values were independently correlated with Ed (beta = -0.351, p = 0.016) and the LV mass/volume ratio (beta = 0.495, p = 0.001). When NT-proBNP was used in the analysis, NT-proBNP was independently correlated with the T1 values (beta = -0.339, p = 0.017). CONCLUSION: Post-contrast T1 is closely related to LV remodeling, diastolic function, and neurohormonal activation in patients with DCM.
