Immunoreactivity of CD99 in Non-Hodgkin's Lymphoma: Unexpected Frequent Expression in ALK-positive Anaplastic Large Cell Lymphoma.
10.3346/jkms.2005.20.6.952
- Author:
Chang Ohk SUNG
1
;
Young H KO
;
Sanghui PARK
;
Kihyun KIM
;
Wonseog KIM
Author Information
1. Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. yhko@smc.samsung.co.kr
- Publication Type:Original Article
- Keywords:
CD99 protein, human;
Lymphoma, Non-Hodgkin;
Lymphoma, Large-Cell, Ki-1
- MeSH:
Antigens, CD/*metabolism;
Blotting, Western;
Cell Adhesion Molecules/*metabolism;
Humans;
Immunohistochemistry;
Lymphoma, Large-Cell/enzymology/*immunology/pathology;
Lymphoma, Non-Hodgkin/enzymology/*immunology/pathology;
Protein-Tyrosine Kinase/immunology/*metabolism
- From:Journal of Korean Medical Science
2005;20(6):952-956
- CountryRepublic of Korea
- Language:English
-
Abstract:
To verify the spectrum of CD99-expressing lymphoid malignancy, an immunohistochemical study for CD99 was carried out in 182 cases of non-Hodgkin's lymphoma, including 21 lymphoblastic lymphomas, 11 small lymphocytic lymphomas, 9 mantle cell lymphomas, 12 follicular lymphomas, 37 diffuse large B cell lymphomas, 18 Burkitt's lymphomas, 28 NK/T-cell lymphomas, 8 angioimmunoblastic T-cell lymphomas, 23 peripheral T-cell lymphomas, unspecified, and 15 systemic anaplastic large cell lymphomas. CD99 was positive in all T-lymphoblastic lymphomas and in 60% of B-lymphoblastic lymphomas. Majority of T and NK cell lymphomas were negative for CD99, except anaplastic large cell lymphomas (ALCLs). Eight of 15 cases (54%) of ALCLs reacted with anti CD99 antibody. Seven of 10 (70%) ALK positive ALCLs expressed CD99, whereas only 1 of 5 (20%) ALK negative ALCLs were positive. Of the mature B-cell lymphomas, 5.4% (2/37) of diffuse large B cell lymphomas and 11.1% (2/18) of Burkitt's lymphomas expressed CD99. In conclusion, CD99 is infrequently expressed in mature B and T cell lymphomas, except ALK-positive ALCL. High expression of CD99 in ALK-positive ALCL is unexpected finding and its biologic and clinical significances have yet to be clarified.
