The Quantitative 18-fluorodeoxyglucose PET Study in the Differential Diagnosis between Idiopathic Parkinson's Disease and Multiple System Atrophy.
- Author:
Chul Hyoung LYOO
1
;
Seung Yeob LEE
;
Young Hoon YOO
;
Myung Sik LEE
Author Information
1. Department of Neurology, Youngdong Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. mslee@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Parkinson disease;
Multiple system atrophy;
Positron-Emission Tomography;
Fluorodeoxyglucose F18;
Corpus striatum;
Cerebellum
- MeSH:
Caudate Nucleus;
Cerebellar Cortex;
Cerebellum;
Corpus Striatum;
Diagnosis, Differential*;
Fluorodeoxyglucose F18;
Glucose;
Humans;
Metabolism;
Multiple System Atrophy*;
Parkinson Disease*;
Positron-Emission Tomography;
Putamen;
Radioactivity;
Sensitivity and Specificity
- From:Journal of the Korean Neurological Association
2006;24(1):31-37
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Overlapping clinical features of idiopathic Parkinson's disease (IPD) and multiple system atrophy (MSA) make it difficult to conduct an accurate differential diagnosis. We performed a quantitative F18- fluorodeoxyglucose PET (FDG PET) and measured the striatal and cerebellar glucose metabolism to evaluate the efficacy of a FDG PET study in the differential diagnosis between IPD and MSA. METHODS: This study included 19 patients with IPD, 28 patients with MSA (MSA-P : MSA-C = 19 : 9) and 12 age matched normal controls. A FDG PET study was performed in all subjects and the original PET image was corrected with the radioactivity curve obtained by repetitive sampling of the radial arterial blood. RESULTS: The measurements of striatal and cerebellar glucose metabolisms of the patients with MSA-P were significantly lower than those of the patients with IPD (P<0.001). However, the measurement of the caudate nucleus provided the most reliable clue for the differential diagnosis between IPD and MSA-P (sensitivity 94.7% and specificity 94.7%). In the patients with MSA-C, the glucose metabolism of the cerebellar vermis (P<0.001), cerebellar cortex (P<0.001) and putamen (P<0.05) was significantly lower than those of the patients with IPD. CONCLUSIONS: Quantitative FDG PET is a useful and reliable method in making a differential diagnosis between IPD and MSA.
