Recent Chemotherapy Reduces the Maximum-Standardized Uptake Value of 18F-Fluoro-Deoxyglucose Positron Emission Tomography in Colorectal Cancer.
- Author:
Minjong LEE
1
;
Tae Sung YEUM
;
Ji Won KIM
;
Sohee OH
;
Shin Ae LEE
;
Hong Ran MOON
;
Young Hoon CHOI
;
Yoo Min HAN
;
Ji Min CHOI
;
Dong Kee JANG
Author Information
1. Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea. kjwjor@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Drug therapy;
FDG-PET/CT;
Colorectal neoplasms
- MeSH:
Aged;
Antineoplastic Agents/*adverse effects;
Chemoradiotherapy, Adjuvant/adverse effects;
Chemotherapy, Adjuvant/adverse effects;
Colorectal Neoplasms/drug therapy/pathology/*radionuclide imaging;
Female;
Fluorodeoxyglucose F18/diagnostic use/*pharmacology;
Humans;
Male;
Neoplasm Invasiveness;
Neoplasm Metastasis;
Positron-Emission Tomography/methods;
Radiopharmaceuticals/diagnostic use/*pharmacology;
Retrospective Studies
- From:Gut and Liver
2014;8(3):254-264
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: The aim of this study was to evaluate the influence of recent chemotherapy on the patterns of the maximum-standardized uptake value (M-SUV) and sensitivity of 18F-fluoro-deoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in colorectal cancer. METHODS: We retrospectively analyzed the FDG-PET/CT of 509 patients who underwent surgery for colorectal cancer. Subgroup analysis was performed according to chemotherapy status; 401 patients were not treated with chemotherapy and 108 patients were treated with chemotherapy within 6 months prior to surgery. Pathologic analysis of the surgical specimen was used as the gold standard. RESULTS: The M-SUV was significantly lower in patients treated with chemotherapy than in those not treated with chemotherapy in pathologically confirmed same stages of disease. The difference in the sensitivity of the M-SUV according to chemotherapy status was greatest using a cutoff M-SUV value of 6.4 (p<0.001). The longest diameter of the primary tumor was the most important factor that correlated with M-SUV of the primary tumor irrespective of the chemotherapy effect (p<0.001). The M-SUV of the primary tumor was not an independent predictor of lymph node metastasis in colorectal cancer. CONCLUSIONS: The results indicate that the M-SUV of FDG-PET/CT should be interpreted in the context of concurrent chemotherapy.
