Glutamine-Supplemented Parenteral Nutrition and Probiotics in Four Adult Autoimmune Enteropathy Patients.
- Author:
Ren Ying XU
1
;
Yan Ping WAN
;
Yi Quan ZHOU
;
Li Ping LU
;
Zhi Qi CHEN
;
Ying Jie WU
;
Wei CAI
Author Information
1. Department of Clinical Nutrition, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. wanyp204@yahoo.com.cn
- Publication Type:Case Reports ; Research Support, Non-U.S. Gov't
- Keywords:
Autoimmune enteropathy;
Malnutrition;
Parenteral nutrition;
Probiotics;
Glutamine
- MeSH:
Adult;
Bifidobacterium;
Enterococcus faecalis;
Female;
Glutamine/*administration & dosage;
Humans;
Lactobacillus acidophilus;
Length of Stay;
Male;
Malnutrition/therapy;
Parenteral Nutrition/*methods;
Polyendocrinopathies, Autoimmune/*therapy;
Probiotics/*administration & dosage;
Young Adult
- From:Gut and Liver
2014;8(3):324-328
- CountryRepublic of Korea
- Language:English
-
Abstract:
To evaluate the effects of glutamine-supplemented parenteral nutrition (PN) and probiotics in adult autoimmune enteropathy (AIE) patients. Four adult AIE patients were identified from April 2006 to January 2012. Clinical and nutritional data were obtained from the patients' medical records. Glutamine-supplemented PN started immediately when the AIE diagnosis was confirmed. The total PN duration was 351 days. According to the PN prescription, the average caloric intake ranged from 20 to 25 kcal/kg/day, and the protein intake ranged from 1.2 to 1.5 g/kg/day. Alanyl-glutamine (20 g/day) was administered to AIE patients for 4 weeks followed by a 2-week break, and this treatment schedule was repeated when PN lasted for more than 6 weeks. Body weight gain and an increased serum albumin level were achieved after PN, and defecation frequency and quality also improved. Each patient received oral supplements, 250 mL of Ensure and two probiotics capsules (each capsule containing 0.5x10(8) colonies) three times a day when enteral nutrition started. Three AIE patients were successfully weaned off PN, and one patient died of pneumonia. Glutamine-supplemented PN and probiotics show promise in managing patients with AIE and related malnutrition.
