Influence of Age, Rate of Obesity, Hepatic Function and Renal Function on Serum Prostate-Specific Antigen in Men Older than 50 Years.
- Author:
Ja Hyeon KU
1
;
Youn Soo JEON
;
Min Eui KIM
;
Nam Kyu LEE
;
Young Ho PARK
;
Jae Ouk AHN
Author Information
1. Military Manpower Administration, Daejeon, Korea. randyku@hanmail. net
- Publication Type:Original Article
- Keywords:
Prostate-specific antigen;
Age;
Health status
- MeSH:
Alanine Transaminase;
Alkaline Phosphatase;
Cholesterol;
Health Promotion;
Humans;
Lipoproteins;
Liver Diseases;
Logistic Models;
Male;
Obesity*;
Potassium;
Prospective Studies;
Prostate-Specific Antigen*;
Risk Factors
- From:Korean Journal of Urology
2001;42(12):1284-1290
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We investigated the influence of age, rate of obesity, hepatic function and renal function on serum prostate-specific antigen in healthy men older than 50 years. MATERIALS AND METHODS: From January 1999 to December 2000, 2,296 healthy Korean men older than 50 years who visited Health Promotion Center at our hospital for a routine health checkup were entered into a prospective study. All men underwent detailed clinical examinations, including serum prostate-specific antigen (PSA) determination using Hybritech Tandem-R assay, anthropometric measurements, tests for liver disease, tests for renal function, and other constitutes. We determined the risk factors of the increase of serum PSA among these clinical parameters using univariate and multivariate logistic regression analyses. RESULTS: The univariate logistic regression analysis indicated that age, alanine aminotransferase (ALT), hemoglobin, potassium, albumin, high-density lipoprotein (HDL) were the risk factors of the increase of serum PSA. In the multivariate model used, age, ALT, alkaline phosphatase, albumin, HDL and cholesterol were an independent predictors of the increase of serum PSA, whereas hemoglobin and potassium lost their statistical significance. CONCLUSIONS: Our findings suggest that the health status as well as may influence on serum PSA level of healthy men older than 50 years. Additional work is needed to determine and validate the clinical significance of these findings.
