A Calcitonin-Negative Neuroendocrine Tumor Derived from Follicular Lesions of the Thyroid.
10.3803/EnM.2015.30.2.221
- Author:
Ga Young KIM
1
;
Chul Yun PARK
;
Chang Ho CHO
;
June Sik PARK
;
Eui Dal JUNG
;
Eon Ju JEON
Author Information
1. Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea. ejjeon@cu.ac.kr
- Publication Type:Case Report
- Keywords:
Calcitonin;
Carcinoma, medullary;
Neuroendocrine tumors
- MeSH:
Adult;
Calcitonin;
Carcinoma, Medullary;
Chromogranin A;
Humans;
Hyperplasia;
Neck;
Neuroendocrine Tumors*;
Pathology, Surgical;
Synaptophysin;
Thyroglobulin;
Thyroid Gland*;
Thyroid Neoplasms;
Thyroid Nodule;
Ultrasonography;
Biomarkers
- From:Endocrinology and Metabolism
2015;30(2):221-225
- CountryRepublic of Korea
- Language:English
-
Abstract:
Neuroendocrine lesions of the thyroid are rare. The most common types are medullary thyroid carcinomas (MTCs) and C-cell hyperplasia. MTCs originate from thyroid parafollicular cells that secrete calcitonin which serves as a serum marker of MTCs. Here, the rare case of a calcitonin-negative neuroendocrine tumor (NET) derived from follicular lesions of the thyroid is described. A 34-year-old man presented at our hospital for the surgical management of an incidental thyroid nodule that was observed on an ultrasound sonography (USG) of the neck. Initially, USG-guided aspiration cytology was performed, and a MTC was suspected. The expressions of thyroglobulin and thyroid transcription factor-1, which are thyroid follicular cell markers, and synaptophysin and chromogranin A, which are neuroendocrine markers, was confirmed following surgical pathology. However, the staining of calcitonin, a marker of MTCs, was not observed. A nonmedullary NET of the thyroid is uncommon, and the distinction between calcitonin-negative NETs and MTCs of the thyroid may be important due to differences in their clinical courses and management.
