Effects of Autologous Platelet-Rich Plasma on Postoperative Blood Loss and Transfusion Requirements in Cardiac Surgery.
10.4097/kjae.1997.32.6.953
- Author:
Yong Woo HONG
1
;
Eun Sook YOO
;
Sou Ouk BANG
;
Young Lan KWAK
;
Gun Ho SONG
;
Choon Soo LEE
;
Sang Beom NAM
;
Myoung Ok KIM
Author Information
1. Department of Anesthesiology, Yonsei Cardiovascular Center and Research Institute, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Transfusion;
platelet-rich plasmapheresis;
Surgery;
cardiac
- MeSH:
Cardiopulmonary Bypass;
Hematocrit;
Humans;
Platelet Count;
Platelet-Rich Plasma*;
Postoperative Hemorrhage*;
Thoracic Surgery*;
Thromboplastin
- From:Korean Journal of Anesthesiology
1997;32(6):953-958
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Patients undergoing cardiac surgery employing cardiopulmonary bypass frequently require transfusion of homologous blood products and, therefore, are exposed to the risk of transfusions. A administration of autologous platelet-rich plasma may reduce homologous transfusion and attendant risks. This study was designed to investigate the effect of preoperative collection of platelet-rich plasma on the requirement of homologous transfusion and postoperative blood loss in patients undergoing open heart surgery. METHODS: Twenty seven patients undergoing cardiac surgery were divided into control group(n=11) and autologous platelet-rich plasmaphereris(PRP) group(n=16). Autologous platelet-rich plasma was retransfused after offbypass. Hematocrit, platelet count, PT(prothrombin time), PTT(partial thromboplastin time), postoperative blood loss and transfusion requirement were measured. RESULTS: There was no statistical significance between control and PRP group in homologous transfusion and postoperative blood loss. There was no difference in hemoatocrit, platelet count, PT or PTT on immediate post surgery or on day 1. CONCLUSIONS: Autologous platelet-rich plasma did not reduce postoperative blood loss or transfusion reguirements in cardiac surgery.
