Effect of Intravenous Fentanyl and Morphine on the Spread of Spinal Analgesia.
10.4097/kjae.1997.32.6.981
- Author:
Dong Hee KIM
1
;
Hye Ra MIN
;
Sang Chul LEE
Author Information
1. Department of Anesthesiology, College of Medicine, Dankook University, Cheon An, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Analgesic;
fentanyl;
morphine;
Anesthesia;
spinal;
Anesthetics;
local;
bupivacaine;
Anesthetic technique;
intravenous;
Antagonist;
narcotic;
naloxone
- MeSH:
Analgesia*;
Analgesics, Opioid;
Anesthesia;
Anesthesia, Spinal;
Anesthetics;
Arthroscopy;
Bupivacaine;
Fentanyl*;
Humans;
Morphine*;
Naloxone
- From:Korean Journal of Anesthesiology
1997;32(6):981-984
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The purpose of this study was to evaluate the effect of different doses of fentanyl and morphine on the spread of spinal analgesia produced by bupivacaine. METHODS: 40 patients undergoing arthroscopy or transurethral resection under spinal anesthesia were randomly assigned to receive intravenous 50 or 100 g of fentanyl(F-50, F-100) or 5, 10 mg of morphine(M-5, M-10). 10 min after, we assessed the new levels of analgesia and administered intravenous naloxone 0.4 mg. The levels of sensory analgesia was reassessed 10 min after naloxone. RESULTS: 10 minutes after intravenous opioids, the level of analgesia increased significantly in M-10 group compared with F-50, M-5 group. Naloxone antagonized the effect of opioids on spinal analgesia. CONCLUSIONS: We conclude that systemic opioids enhance the spread of analgesia in a dose dependent manner, and this enhancement was antagonized by naloxone.
