Microbial Profile of the Stomach: Comparison between Normal Mucosa and Cancer Tissue in the Same Patient.
10.4167/jbv.2014.44.2.162
- Author:
Incheol SEO
1
;
Bijay Kumar JHA
;
Seong Il SUH
;
Min Ho SUH
;
Won Ki BAEK
Author Information
1. Department of Microbiology, School of Medicine, Keimyung University, Daegu, Korea. wonki@dsmc.or.kr
- Publication Type:Original Article
- Keywords:
Gastric cancer;
Helicobacter pylori;
Microbiome
- MeSH:
Aging;
Asia;
Cause of Death;
Clostridium;
Corynebacterium;
Gastric Mucosa;
Helicobacter pylori;
Humans;
Microbiota;
Mortality;
Mucous Membrane*;
Prevotella;
Propionibacterium;
Staphylococcus;
Stomach Neoplasms;
Stomach*
- From:Journal of Bacteriology and Virology
2014;44(2):162-169
- CountryRepublic of Korea
- Language:English
-
Abstract:
Gastric cancer is the third most common cancer and the third most frequent cause of cancer mortality in Asia. It is predicted that gastric cancer will remain an important cause of death at least during the next half century because of the increasing number of new cases in an aging population. However, little has been revealed about the role of gastric microbes and their reaction to gastric cancer. In this study, we identified differences in the microbial communities between gastric cancer and normal gastric mucosa by comparing the microbiomes of tissues from the same patients. The clustering analysis results showed different bacterial communities between normal gastric mucosa and gastric cancer. A comparison of bacterial communities at the species level revealed that Helicobacter pylori was significantly reduced in cancer tissue compared to that in normal gastric mucosa in the same patient. A comparison at the genus level showed that Propionibacterium spp., Staphylococcus spp., and Corynebacterium spp. had significantly reduced populations in cancer tissue, whereas Clostridium spp. and Prevotella spp. had significantly increased populations in cancer tissue.
