Role of Cyclic GMP-AMP Synthase in Sensing Human Immunodeficiency Virus.
10.4167/jbv.2014.44.2.206
- Author:
Yeon Soo PARK
1
;
Im Hyeon KIM
;
Young Sang KOH
Author Information
1. Jeju National University School of Medicine, Jeju, Korea. yskoh7@jejunu.ac.kr
- Publication Type:Letter
- Keywords:
cGAMP synthase (cGAS);
Retroviruses;
Human immunodeficiency virus;
Innate immune system
- MeSH:
Adenosine Monophosphate;
Animals;
Cell Line;
Cytokines;
DNA;
Guanosine Monophosphate;
HIV Infections;
HIV Reverse Transcriptase;
HIV*;
Humans;
Immunity, Innate;
Interferon-beta;
Mice;
Retroviridae
- From:Journal of Bacteriology and Virology
2014;44(2):206-207
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Cyclic guanosine monophosphate adenosine monophosphate (cGAMP) synthase (cGAS) detects human immunodeficiency virus (HIV) and produces cGAMP to induce cytokines. Reverse transcribed DNA of HIV is critical for triggering innate immune responses as inhibitor of HIV reverse transcriptase blocked the induction of interferon-beta by the virus. Furthermore, knockout of cGAS in human or mouse cell lines abrogated the production of cytokines by HIV infection highlighting the essential role of cGAS in detection of HIV and other retroviruses.
