Does Epidural Clonidine Decrease the Sevoflurane Concentration for Maintaining the BIS 50?.
10.4097/kjae.2006.50.1.60
- Author:
Young Jun BAHN
1
;
Hye Won LEE
;
Choon Hak LIM
;
Hae Ja LIM
;
Suk Min YOON
Author Information
1. Department of Anesthesiology and Pain Medicine, College of Medicine, Korea University, Seoul, Korea. hyewonmd@unitel.co.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
BIS;
end-tidal sevoflurane concentration;
epidural clonidine
- MeSH:
Anesthesia, General;
Arterial Pressure;
Blood Pressure;
Clonidine*;
Female;
Gynecologic Surgical Procedures;
Heart Rate;
Humans;
Premedication;
Thiopental;
Vecuronium Bromide
- From:Korean Journal of Anesthesiology
2006;50(1):60-65
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The aim of this study was to investigate the influence of epidural clonidine on the BIS, and its potential dose-sparing effect on the sevoflurane requirement for maintaining the BIS 50. METHODS: Forty ASA I or II patients aged 20 to 65, undergoing lower abdominal, gynecologic surgery under general anesthesia, were randomly allocated to either a 10 ml epidural normal saline injection group (n = 20) or a 10 ml epidural clonidine 3microgram/kg mixed with normal saline injection group (n = 20). They received 5 mg/kg thiopental sodium and 0.1 mg/kg vecuronium bromide for induction, with no premedication. After surgical incision, the sevoflurane concentration was controlled to maintain the BIS 50. Epidural saline or clonidine was then injected and end-tidal sevoflurane concentration to maintain the BIS 50, the heart rate (HR) and mean arterial pressure (MBP) were measured every 5 min over a 20 minute period. RESULTS: The end-tidal sevoflurane concentration in the clonidine group decreased by 27.5% after the epidural clonidine injection (1.49 +/- 0.23 vol% vs. 1.08 +/- 0.27 vol%; P<0.05) compared with the saline group (1.36 +/- 0.18 vol% vs. 1.33 +/- 0.21 vol%; P>0.05). There were no changes in the heart rate and mean blood pressure in either group. CONCLUSIONS: Epidural clonidine causes a significant decrease in the BIS, and lowers the end-tidal sevoflurane concentration required for maintaining the BIS 50.
