Evaluation for usefulness of bone marrow study in fever of unknown origin.
- Author:
Yeong Sic KIM
1
;
Woo In LEE
;
Jin Tae SUH
;
Hee Joo LEE
Author Information
1. Department of Clinical Pathology, College of Medicine, Kyung Hee University, Seoul, Korea
- Publication Type:Original Article
- Keywords:
FUO;
bone marrow study
- MeSH:
Anemia, Aplastic;
Bacterial Infections;
Biopsy;
Bone Marrow Examination;
Bone Marrow*;
Chemistry;
Diagnosis;
Fever of Unknown Origin*;
Fever*;
Hematologic Diseases;
Humans;
Lymphadenitis;
Retrospective Studies;
Tuberculosis, Miliary
- From:Korean Journal of Clinical Pathology
1999;19(6):598-601
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: As the new diagnostic methods for evaluation of fever of unknown origin (FUO) have been developed, the clinical spectrum of FUO has been changed. Although bone marrow study was commonly used in the evaluation of FUO, it's value has not been established. We evaluated the value of bone marrow study for FUO patients. MATERIAL AND METHODS: The 53 patients with FUO who have been performed bone marrow study from 1991 to 1998 were studied, retrospectively. Radiologic, serologic, hematologic, biopsy of tissue, chemistry, molecular and microbiologic review were included in this study. RESULTS: The etiology of FUO was identified in 31(58.5%) of the 53 patients through bone marrow examination. Of 53 patients, bacterial infection accounts for 12(22.6%); neoplasm 10(18.9%); SLE 3(5.7%); aplastic anemia 2(3.8%); drug induced 2(3.8%); necrotizing lymphadenitis 1(1.8%); hereditary spherocytosis 1(1.8%). Bone marrow examination as confirmative diagnostic method was valuable in 12(38.7%) of 31 patients who's etiology was identified. Of 53 patients, 22 persons (41.5%) showed no abnormal findings in marrow. CONCLUSION: Bone marrow study for FUO was very useful to diagnose hematologic diseases and miliary tuberculosis, but it was considered to be a less useful method for the initial diagnosis for the other diseases.
