Polymorphisms at the Lipoprotein Lipase Gene: Possible Associations with Coronary Artery Disease and Blood Lipid Levels in Koreans.
- Author:
Hyun Jin CHUNG
1
;
Yoe Min YOON
;
Tae Hee HAN
;
Hyosoon PARK
;
Junghan SONG
;
Jin Q KIM
Author Information
1. Department of Clinical Pathology, Seoul National University College of Medicine, Seoul, Korea
- Publication Type:Original Article
- Keywords:
Lipoprotein lipase (LPL) gene polymorphism;
Coronary artery disease (CAD);
Lipid level
- MeSH:
Coronary Artery Disease*;
Coronary Vessels*;
Digestion;
DNA;
Genotype;
Humans;
Linkage Disequilibrium;
Lipoprotein Lipase*;
Lipoproteins*;
Triglycerides
- From:Korean Journal of Clinical Pathology
1999;19(6):617-623
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Lipoprotein lipase (LPL) gene polymorphisms have been found associated with coronary artery disease (CAD) and lipid levels, but their impact is less clearly established. The analysis of associations of LPL gene polymorphisms with CAD and lipid levels in Koreans was investigated. METHODS: Analysis of PvuII (intron 6), HindIII (intron 8), and Ser447-Ter (exon 9) polymorphisms of LPL gene were performed using restriction enzyme digestion of amplified DNA products and lipid levels were analyzed in healthy control subjects (n=228) and patients with CAD (n=166). RESULTS: PvuII, HindIII, and Ser447-Ter sites were in strong linkage disequilibrium. No statistical differences in the genotypic frequencies of PvuII, HindIII, and Ser447-Ter polymorphisms were observed between control and CAD groups. P2P2 genotype had higher triglyceride level in CAD group and lower HDL-cholesterol level in control group than the other genotypes (P1P1, P1P2). H2H2 genotype had higher triglyceride level in CAD group and lower HDL-cholesterol level in control group than the other genotypes (H1H1, H1H2). CONCLUSIONS: Genotypes of LPL PvuII, HindIII, and Ser447-Ter polymorphisms were not associated with CAD. Individuals with P2P2 and H2H2 genotypes, however, had higher triglyceride and lower HDL-cholesterol levels that is known to be the most commmon dyslipidaemia in CAD patients.
