Cerebral Aspergillosis with Multiple Enhancing Nodules in the Right Cerebral Hemisphere in the Immune-Competent Patient.
10.3340/jkns.2013.53.5.312
- Author:
Gwang Jun LEE
1
;
Tae Young JUNG
;
Seong Min CHOI
;
Min Young JUNG
Author Information
1. Department of Neurosurgery, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hwasun Hospital & Medical School, Gwangju, Korea. jung-ty@chonnam.ac.kr
- Publication Type:Case Report
- Keywords:
Aspergillosis;
Cerebral;
Enhancement;
Immune-competent;
Multiple
- MeSH:
Abscess;
Amphotericin B;
Antifungal Agents;
Aspergillosis;
Aspergillus;
Biopsy;
Brain;
Brain Abscess;
Central Nervous System;
Cerebrum;
Diabetes Mellitus;
Diffusion;
Follow-Up Studies;
Humans;
Magnetic Resonance Imaging;
Rare Diseases;
Recurrence;
Vision, Ocular
- From:Journal of Korean Neurosurgical Society
2013;53(5):312-315
- CountryRepublic of Korea
- Language:English
-
Abstract:
Aspergillosis in the central nervous system (CNS) is a very rare disease in immune-competent patients. There was a case of a healthy man without a history of immune-compromised disease who had invasive aspergillosis with unusual radiologic findings. A 48-year-old healthy man with diabetes mellitus, presented with complaints of blurred vision that persisted for one month. Brain magnetic resonance imaging (MRI) showed multiple nodular enhancing lesions on the right cerebral hemisphere. The diffusion image appeared in a high-signal intensity in these areas. Cerebrospinal fluid examination did not show any infection signs. An open biopsy was done and intraoperative findings showed grayish inflammatory and necrotic tissue without a definitive mass lesion. The pathologic result was a brain abscess caused by fungal infection, morphologically aspergillus. Antifungal agents (Amphotericin B, Ambisome and Voriconazole) were used for treatment for 3 months. The visual symptoms improved. There was no recurrence or abscess pocket, but the remaining focal enhanced lesions were visible in the right temporal and occipital area at a one year follow-up MRI. This immune-competent patient showed multiple enhancing CNS aspergillosis in the cerebral hemisphere, which had a good outcome with antifungal agents.
