Dopamine Transporter Density of the Basal Ganglia in Children with Attention Deficit Hyperactivity Disorder Assessed with I-123 IPT SPECT.
- Author:
Keun Ah CHEON
1
;
Young Hoon RYU
;
Young Kee KIM
;
Kee NAMKOONG
;
Chan Hyung KIM
Author Information
1. Department of Psychiatry, College of Medicine, Yonsei University, Seoul, Korea. kacheon@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
ADHD;
I-123 IPT SPECT;
Basal ganglia;
Dopamine transporter density
- MeSH:
Administration, Intravenous;
Attention Deficit Disorder with Hyperactivity*;
Basal Ganglia*;
Brain;
Child*;
Dopamine Plasma Membrane Transport Proteins*;
Dopamine*;
Humans;
Neurotransmitter Agents;
Tomography, Emission-Computed, Single-Photon*
- From:Korean Journal of Psychopharmacology
2002;13(2):95-103
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: ADHD has been known as a psychiatric disorder in childhood associated with dopamine dysregulation. In the present study, we investigated dopamine transporter (DAT) density using I-123N-(3-iodopropen-2-yl)-2beta-carbomethoxy-3beta-(4-chlorophenyl) tropane (I-123-IPT)-SPECT in children with ADHD on the hypothesis that alterations of DAT density in the basal ganglia were suggestive of dopaminergic dysfunction in children with ADHD. METHODS: Nine drug-naive children with ADHD and six normal children were included in the study. We performed brain SPECT two hours after the intravenous administration of I-123-IPT and made both quantitative and qualitative analyses using the obtained SPECT data, which were reconstructed for the assessment of specific/nonspecific DAT binding ratios in the basal ganglia. We then investigated the correlation between ADHD Rating Scale (ARS) scores of children with ADHD and specific/nonspecific DAT binding ratios in the basal ganglia. RESULTS: Children with ADHD had significantly greater specific/nonspecific DAT binding ratio of the basal ganglia comparing to normal children. However, no significant correlation were found between ARS scores of children with ADHD and specific/nonspecific DAT binding ratio of basal ganglia in children with ADHD. CONCLUSION: These findings support the complex dysregulation of the dopaminergic neurotransmitter system in children with ADHD.
