Two Cases of Leukemia Cutis Showing Clinical Improvement with Systemic Retinoid Administration.
- Author:
Jae Wang KIM
;
Kwang Joong KIM
;
Jong Min KIM
;
Chong Ju LEE
- Publication Type:Case Report
- MeSH:
Clone Cells;
Humans;
Leukemia*;
Leukemia, Promyelocytic, Acute;
Signal Transduction;
Tretinoin
- From:Korean Journal of Dermatology
1998;36(5):901-905
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Herein we report two cases of leukemia cutis that were responsive to oral all-tratm retinoic acid(ATRA) therapy. The two presented patients, who had been diagnosed with acute pmmyelocytic leukemia, disclosed specific lesions of leukemia cutis through histopathological examinations. Leukemia cutis due to acute promyelocytic leukemia is characterized by PML/RAR-a chimeric fusion proteins which arise from chromosomal trmslocation. This PML/RAR-a transcript can be a valuable molecular therapeutic target to systemic retinoid therapy in that ATRA induces terminal differentiation of leukemic clones and PML/RAR-a transcript preserves the ATRA-responsive signal transduction pathway. We concluded that leukemia cutis might be treated by tretinoin therapy without notifi.able adverse effects.
