Sensitization to Multiple Rh Antigens by Transfusion of Random Donor Platelet Concentrates in a -D- Phenotype Patient.
10.3343/alm.2012.32.6.429
- Author:
Jae Won YUN
1
;
Eun Suk KANG
;
Chang Seok KI
;
Kwang Cheol KOH
;
Dae Won KIM
Author Information
1. Department of Laboratory Medicine & Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. dwsmc.kim@samsung.com
- Publication Type:Brief Communication
- Keywords:
Rh-Hr blood group system;
Rh isoimmunization;
Platelet transfusion
- From:Annals of Laboratory Medicine
2012;32(6):429-432
- CountryRepublic of Korea
- Language:English
-
Abstract:
The -D- phenotype is a rare Rh phenotype that strongly expresses D antigen without C, c, E, or e antigens. In -D- phenotype individuals, anti-Rh17 (Hro) is commonly found if there is a history of pregnancy or transfusion with red blood cells (RBCs) that express C, c, E, or e antigens. We report the first case of a -D- phenotype patient with multiple Rh antibodies including anti-Rh17 who had a history of two occasions of transfusion with eight random donor platelet concentrates two and six years ago. We found that a trivial amount of RBCs in the platelet components was able to trigger sensitization to RBC antigens, especially the highly immunogenic and clinically significant Rh antigens, including C, c, E, e or CcEe polypeptides. To avoid unnecessary sensitization and to minimize the risk of hemolytic transfusion reactions in patients with this rare Rh phenotype, a modified strategy for pretransfusion screenings needs to be discussed in the field of transfusion medicine.
