The Relationship between Subclinical Thyroid Disease and Cardiovascular Disease Risk Score in Koreans.
10.3346/jkms.2017.32.10.1626
- Author:
Hee Joong LIM
1
;
Seong Hee AHN
;
Seongbin HONG
;
Young Ju SUH
Author Information
1. Department of Medicine, Inha University College of Medicine, Incheon, Korea.
- Publication Type:Original Article
- Keywords:
Subclinical Hyperthyroidism;
Subclinical Hypothyroidism;
Thyroid Stimulating Hormone;
Cardiovascular Diseases;
Korean;
Framingham Risk Score
- MeSH:
Body Mass Index;
Cardiovascular Diseases*;
Cohort Studies;
Female;
Humans;
Hyperthyroidism;
Hypothyroidism;
Iodine;
Korea;
Least-Squares Analysis;
Leukocytes;
Linear Models;
Nutrition Surveys;
Reference Values;
Risk Factors;
Thyroid Diseases*;
Thyroid Gland*;
Thyrotropin;
Thyroxine
- From:Journal of Korean Medical Science
2017;32(10):1626-1632
- CountryRepublic of Korea
- Language:English
-
Abstract:
Subclinical hyperthyroidism and subclinical hypothyroidism are characterized by abnormal thyroid stimulating hormone (TSH) with normal free thyroxine. Subclinical thyroid diseases, to date, have received less attention compared with other thyroid diseases since they are asymptomatic. This study aimed to verify the association between subclinical thyroid diseases and cardiovascular diseases (CVDs) risk score in the Korean population. This was a population-based cohort study using data collected from 3,722 subjects (aged ≥ 30 years) during the 6th Korea National Health and Nutrition Examination Survey (KNHANES VI; 2013–2015). Gender-specific Framingham risk scores were calculated to identify the association between subclinical thyroid diseases and 10-year CVD risk score. Complex survey, with consideration of sampling weight, was analyzed using generalized linear models after stratification by gender. The TSH reference range was between 0.61 and 6.91 mIU/L in this study. TSH showed a positive association with the 10-year CVD risk score only in the female population (P = 0.001). There were significant differences in the least squares means of 10-year CVD risk score by the effect of subclinical hypothyroidism compared with euthyroidism (normal group) in females, after adjusting for body mass index, white blood cell, and urine iodine (P = 0.006 and Bonferroni corrected P = 0.012). In conclusion, subclinical hypothyroidism is associated with increased 10-year CVD risk score in the female Korean population aged 30 years or more. Therefore, we recommend to clinically checkup major CVD risk factors in female patients with subclinical hypothyroidism aged 30 years or more.
