A case of nephrotic syndrome associated with protein S deficiency and cerebral thrombosis.
10.3346/jkms.1994.9.4.347
- Author:
Kyung Soon SONG
1
;
Dong Il WON
;
An Na LEE
;
Chung Ho KIM
;
Jin Soo KIM
Author Information
1. Department of Clinical Pathology, College of Medicine, Yonsei University, Seoul, Korea.
- Publication Type:Case Reports
- Keywords:
Protein S;
thrombosis;
nephrotic syndrome
- MeSH:
Adult;
Case Report;
Female;
Human;
Intracranial Embolism and Thrombosis/*etiology;
Nephrotic Syndrome/*complications;
Protein S Deficiency/*complications
- From:Journal of Korean Medical Science
1994;9(4):347-350
- CountryRepublic of Korea
- Language:English
-
Abstract:
Protein S is found in two forms in plasma; as free and functionally active protein S, and complexed to C4b-binding protein. Patients with nephrotic syndrome are at risk for arterial and venous thrombosis at various localizations, and acquired protein S deficiency due to the selective urinary loss of the free form may be a risk factor for the development of thromboembolic complications. We report a case of cerebral arterial thrombosis associated with decreased level of free protein S antigen (44%) in a 39-year-old female patient with nephrotic syndrome.
