Angiopoietins in Diabetic Nephropathy.
- Author:
Eun Young LEE
1
;
Hyo Wook GIL
;
Jong Oh YANG
;
Jang Hyun KOH
;
Choon Hee CHUNG
;
Sae Yong HONG
Author Information
1. Department of Internal Medicine and Clinical Research Institute, SoonChunHyang University Cheonan Hospital, Cheonan, Korea. eylee@sch.ac.kr
- Publication Type:Original Article
- Keywords:
Angiopoietin-1;
Angiopoietin-2;
Diabetic nephropathy;
Nephrin;
Tie-2 receptor
- MeSH:
Albuminuria;
Angiopoietin-1;
Angiopoietin-2;
Angiopoietins*;
Animals;
Diabetic Nephropathies*;
Glomerular Filtration Barrier;
Glomerulonephritis;
Hypertrophy;
Peroxisomes;
Rats;
Receptor, TIE-2;
Receptors, Angiotensin;
Thioctic Acid
- From:Korean Journal of Nephrology
2007;26(3):311-319
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: It has been reported that angiopoietins and Tie-2 receptor play an important role in the maintenance of glomerular filtration barrier in various glomerulonephritis models. We studied the role of angiopoietins on renal injury in diabetes. METHODS: In this study, we examined the changes of angiopoietin-1, angiopoietin-2, Tie-2 receptor, and nephrin expression in the experimental diabetic nephropathy and also determined whether these changes were modified by renoprotective intervention by angiotensin II receptor blocker, alpha-lipoic acid, and peroxisome proliferator activated receptor (PPAR)-agonist. RESULTS: A marked increase in urinary albumin excretion and glomerular volume was observed in diabetic rats. Renal angiopoietin-2 and Tie-2 receptor expression were significantly higher in diabetic rats than in the control groups, with a significant reduction in renal angiopoietin-2 expression, albuminuria, and renal hypertrophy in angiotensin II receptor blocker-treated diabetic rats. And there was a significant reduction in renal Tie-2 expression and renal hypertrophy in alpha-lipoic acid-treated and PPAR-gamma agonist-treated diabetic rats. CONCLUSION: These results demonstrate that the dysregulation of angiopoietins and Tie-2 receptor can lead to renal hypertrophy and albuminuria. Angiotensin II receptor blocker, alpha-lipoic acid, and PPAR-gamma agonist attenuated these changes in angiopoietins and/or Tie-2 expression and prevented the development of albuminuria and renal hypertrophy in vivo.