A Case of Gastric Cancer Presenting Acute Disseminated Intravascular Coagulation Palliated with Combination Chemotherapy of Irinotecan and Cisplatin.
10.5230/jkgca.2006.6.3.189
- Author:
Sang Hoon LEE
1
;
In Sook WOO
;
Seon Young KI
;
Myung Jun SONG
;
Sang Young RHO
;
Su Jin KOH
;
Myung Ah LEE
;
Jin Hyoung KANG
;
Young Seon HONG
;
Myung Gyu CHOI
;
Kyung Shik LEE
Author Information
1. Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. insookwoo@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Gastric cancer;
Irinotecan;
Disseminated intravascular coagulation
- MeSH:
Bone Marrow;
Cisplatin*;
Dacarbazine;
Diagnosis;
Disease Progression;
Disseminated Intravascular Coagulation*;
Drug Therapy;
Drug Therapy, Combination*;
Dyspnea;
Female;
Hemorrhage;
Humans;
Middle Aged;
Neoplasm Metastasis;
Stomach Neoplasms*;
Uterine Hemorrhage
- From:Journal of the Korean Gastric Cancer Association
2006;6(3):189-192
- CountryRepublic of Korea
- Language:English
-
Abstract:
Acute disseminated intravascular coagulation (DIC) associated with gastric cancer is not common and has short survival of 1 to 3 weeks. Systemic chemotherapy in spite of hematologic unstability for gastric cancer may prolong survival time. A 47-year-old woman who complained of dyspnea, vaginal bleeding and easy bruisibility was diagnosed to stage IV gastric cancer with acute disseminated intravascular coagulation based on the laboratory data. She also had multiple bone metastases and bone marrow involvement. This is the first case treated with combination chemotherapy of irinotecan and cisplatin for advanced gastric cancer complicated by disseminated intravascular coagulation at the time of diagnosis. With systemic chemotherapy, some of the bleeding symptoms and the DIC process improved, even not completely recovered. However the patient died of disease progression and survival time was 12 weeks.
