The Diagnostic Value of Contrast Enhanced Power Doppler US on Small Breast Lesions.
10.3348/jkrs.2002.47.2.233
- Author:
Kwang Chul LEE
1
;
Shin Ho KOOK
;
Yong Lai PARK
;
Won Kil PAE
;
Young Rae LEE
;
Eun Chul CHUNG
;
Hae Won PARK
Author Information
1. Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Korea. kook3@samsung.co.kr
- Publication Type:Original Article
- Keywords:
Breast neoplasms, diagnosis;
Ultrasound (US), contrast media
- MeSH:
Breast*;
Complement System Proteins;
Hemodynamics;
Microbubbles;
Prospective Studies;
Sensitivity and Specificity;
Ultrasonography, Doppler
- From:Journal of the Korean Radiological Society
2002;47(2):233-239
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the usefulness of contrast-enhanced power Doppler ultrasonography (PDUS) in differentiating small benign from small malignant breast lesions. MATERIALS AND METHODS: Thirty-one solid breast lesions (<2 cm in size; 17 benign and 14 malignant) prospectively underwent US and PDUS before and after the injection of contrast agent (SH U 508A). Morphologic analysis involved independent assessment of the findings of US and the patterns of Doppler signals before and after contrast enhancement at PDUS, and sensitivity and specificity were thus evaluated. The diagnostic accuracy of US accompanied by PDUS was also determined before and after contrast enhancement. Hemodynamic analysis involved measurement of the time lapse between contrast injection at PDUS and observed change in Doppler signals. For this, a sonic VIOR computer-assisted program was used and the results were correlated with the pathologic findings. RESULTS: The sensitivities of US before and after contrast enhanced PDUS were 100%, 35.7%, and 57%, with specificities of 47%, 88.2% and 76%, respectively. The diagnostic accuracy of US was 35% with noncontrast PDUS, and 77% before and after contrast enhanced PDUS. The recorded time lapse between contrast injection at PDUS and observed change in Doppler signals did not correlate closely with the pathologic findings. CONCLUSION: In that it improved visualization of the morphology of vascular Doppler signals, microbubble contrast-enhanced PDUS complemented US and PDUS in differentiating between small benign and small malignant breast lesions.
