Intramyocardial Injection of Stem Cells in Pig Myocardial Infarction Model: The First Trial in Korea.
10.3346/jkms.2017.32.10.1708
- Author:
Min Chul KIM
1
;
Yong Sook KIM
;
Wan Seok KANG
;
Ki Hong LEE
;
Meeyoung CHO
;
Moon Hwa HONG
;
Kyung Seob LIM
;
Myung Ho JEONG
;
Youngkeun AHN
Author Information
1. Department of Cardiology, Chonnam National University Hospital, Gwangju, Korea. cecilyk@hanmail.net
- Publication Type:Brief Communication
- Keywords:
Mesenchymal Stem Cell Transplantation;
Heart Failure;
Myocardial Infarction
- MeSH:
Cell- and Tissue-Based Therapy;
Heart;
Heart Failure;
Korea*;
Mesenchymal Stem Cell Transplantation;
Mesenchymal Stromal Cells;
Myocardial Infarction*;
Stem Cells*;
Swine
- From:Journal of Korean Medical Science
2017;32(10):1708-1712
- CountryRepublic of Korea
- Language:English
-
Abstract:
Although cell therapy is emerged for cardiac repair, its efficacy is modest by intracoronary infusion. Therefore, we established the intramyocardial delivery technique using a left ventricular (LV) mapping system (NOGA® XP) using 18 pigs. After adipose tissue-derived mesenchymal stem cells (ATSCs) were delivered intramyocardially to porcine infarcted heart, LV ejection fraction (EF) was increased, and LV chamber size was decreased. We proved the therapeutic effect of intramyocardial injection of ATSC through a LV mapping system in the porcine model for the first time in Korea. The adoption of this technique may accelerate the translation into a clinical application in the near future.
