Isolated Extramedullary Relapse of Acute Myelogenous Leukemia as a Uterine Granulocytic Sarcoma in an Allogeneic Hematopoietic Stem Cell Transplantation Recipient.
10.3349/ymj.2004.45.2.330
- Author:
Hoyoung MAENG
1
;
June Won CHEONG
;
Seung Tae LEE
;
Woo Ick YANG
;
Jee Sook HAHN
;
Yun Woong KO
;
Yoo Hong MIN
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. minbrmmd@yumc.yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Acute myelogenous leukemia;
relapse;
uterus;
bone marrow transplantation
- MeSH:
Adult;
Female;
Hematopoietic Stem Cell Transplantation/*adverse effects;
Human;
Leukemia, Myelocytic, Acute/*pathology/*therapy;
Neoplasm Recurrence, Local;
Sarcoma, Granulocytic/etiology/*pathology;
Uterine Neoplasms/etiology/*pathology
- From:Yonsei Medical Journal
2004;45(2):330-333
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report an unusual case of acute myelogenous leukemia in a patient who showed an extramedullary relapse in her uterus, without bone marrow recurrence, two years after an allogeneic bone marrow transplant. She complained of irregular vaginal spotting, and magnetic resonance imaging demonstrated a uterine mass. A biopsy revealed a massive infiltration of immature myeloid cells. A variable number of tandem repeats (VNTR) based on an examination of peripheral blood cells showed full donor chimerism. After receiving chemotherapy, her uterine mass had completely resolved. She has remained in complete remission for more than 6 months. This case suggests that physicians should be aware of the possibility of a uterine relapse in female bone marrow transplant recipients with acute myelogenous leukemia.
