Retrospective Study on the Impact of Hepatitis B and Hepatitis C Virus Infection on Renal Transplnat Recipients Over 15 Years.
- Author:
Byung Kee BANG
1
;
Bum Soon CHOI
;
Hyung Wook KIM
;
Sung Kwon KIM
;
Chul Woo YANG
;
Yong Soo KIM
;
Suk Young KIM
;
Euy Jin CHOI
;
Yoon Sik CHANG
Author Information
1. Department of Internal Medicine, Medical College, The Catholic University of Korea, Seoul, Korea. Nephron@cmc.cuk.ac.kr
- Publication Type:Original Article
- Keywords:
Kidney transplantation;
Hepatitis B;
Hepatitis C
- MeSH:
Cause of Death;
Follow-Up Studies;
Graft Survival;
Hepacivirus*;
Hepatitis B Surface Antigens;
Hepatitis B virus;
Hepatitis B*;
Hepatitis C*;
Hepatitis*;
Humans;
Kidney;
Kidney Transplantation;
Liver;
Liver Diseases;
Mass Screening;
Mortality;
Prevalence;
Retrospective Studies*;
Survival Rate;
Transplants
- From:Korean Journal of Nephrology
2002;21(3):423-434
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The impact of hepatitis B or hepatitis C virus infection on renal transplantation outcome is controversial. The aim of this study is to assess the impact of hepatitis B and hepatitis C infection on kidney transplant over the long-term, 15 years and to compare infected patients with noninfected patients matched for factors possibly associated with graft and patient survival. METHODS: We analyzed 1,042 patients who underwent renal transplantation in period from March 1984 to Dec. 1998 including 107 with positive HBsAg (HBV(+) group), 81 with positive anti-HCV antibody (HCV(+) group) and 714 noninfected recipients (NBNC group). One hundred-forty patients who had not taken ani-HCV antibody screening test were excluded. The prevalence of chronic liver disease, the patient mortality, the patient survival rate and the graft survival rate were evaluated. RESULTS: The patient mortality during the period of follow-up was significantly higher in HBV(+) group(32.7%) than in HCV(+) group(9.9%) and NBNC group(8.4%). The cause of death related to liver desease was significantly higher in HBV(+) group(57.1%) than HCV(+) group(0%) and NBNC group(1.7%). Five year and 10 year graft survival rate were significantly lower in HBV(+) group(52.2 %, 39.2%) than in HCV(+) group(68.4%, 47.2%) and NBNC group(86.6%, 65.8%). Five year and 10 year patient survival rate of HBV(+) group(72.0%, 68.9%) was significantly lower than HCV(+) group(91.6%, 87.3%) and NBNC group(94.4%, 88.2%), but there was no significant difference in the patient survival rate between HCV(+) and NBNC group. CONCLUSION: Hepatitis B virus infection has a significant deleterious effect on the patient and graft survival of renal transplantation recipients. The poor survival rate was a result of the mortality from liver disorder. Hepatitis C virus infection also has a poor graft survival rate compared to NBNC group, but the patient survial rate is similar to NBNC group.
