Severe Symptomatic Hyponatremia Caused by Low Dose Oral Cyclophosphamide: A Case Report.
- Author:
Seungkyo PARK
1
;
Woojeung KIM
;
Hoon Young CHOI
;
Ji Hyun YOON
;
Sung Kyu HA
;
Hyeong Cheon PARK
Author Information
1. Division of Nephrology, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. amp97@yuhs.ac
- Publication Type:Case Report
- Keywords:
Hyponatremia;
Cyclophosphamide;
ANCA associated vasculitis
- MeSH:
Aged;
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis;
Antibodies, Antineutrophil Cytoplasmic;
Cyclophosphamide;
Female;
Glomerulonephritis;
Humans;
Hyponatremia
- From:Korean Journal of Nephrology
2011;30(6):647-650
- CountryRepublic of Korea
- Language:English
-
Abstract:
Cyclophosphamide (CY), an alkylating agent, is frequently used in the treatment of various autoimmune disorders and malignancies. Acute hyponatremia is a well-known side effect of moderate to high dose intravenous CY treatment, but is rare in patients treated with low dose intravenous CY. We report the case of a severe symptomatic hyponatremia in a 68-year-old woman with renal impairment who was treated with oral CY (100 mg/day) for anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis (GN). This case demonstrates that even oral CY could be associated with life threatening acute hyponatremia and should be used with caution.
