A Case of Primary Hyperoxaluria with Renal Allograft Dysfunction.
- Author:
Eun Joo SONG
1
;
Jang Hee CHO
;
Young Deuk YOON
;
Ja Yong PARK
;
Ji Young CHOI
;
Se Hee YOON
;
Yon Su KIM
;
Chan Duck KIM
;
Yong Lim KIM
;
Sun Hee PARK
Author Information
1. Department of Internal Medicine, Kyungpook National University, Daegu, Korea. sh-park@knu.ac.kr
- Publication Type:Case Report
- Keywords:
Oxalate;
Primary hyperoxaluria;
Kidney transplantation
- MeSH:
Glyoxylates;
Humans;
Hyperoxaluria, Primary;
Kidney;
Kidney Failure, Chronic;
Kidney Transplantation;
Nephrocalcinosis;
Population Characteristics;
Renal Insufficiency;
Transplantation, Homologous;
Transplants;
Urolithiasis
- From:Korean Journal of Nephrology
2011;30(6):676-681
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Primary hyperoxaluria is a rare disorder of glyoxylate metabolism in which hepatic enzyme deficiencies result in overproduction of oxalate. The resulting elevation of urinary oxalate excretion leads to recurrent urolithiasis and progressive nephrocalcinosis. End-stage renal disease frequently occurs and is accompanied by systemic oxalate deposition along with its harmful effects. With the rarity and various clinical heterogeneity of the disease, the high proportion of patients in whom diagnosis is made after advanced renal failure have developed it. On account of its high rate of graft loss associated with primary hyperoxaluria, isolated kidney transplantation has been replaced by combined liver/kidney transplantation. In this report, we describe a case of primary hyperoxaluria with kidney graft failure who had a history of recurrent renal stones.
