Pathologic Characteristics and Differential Diagnosis of Hodgkin Lymphoma.
- Author:
Hee Jeong CHA
1
;
Jooryung HUH
Author Information
1. Department of Pathology, Ulsan University Hospital, Ulsan, Korea.
- Publication Type:Review
- Keywords:
Classical Hodgkin lymphoma;
Nodular lymphocyte predominant Hodgkin's lymphoma
- MeSH:
B-Lymphocytes;
Biology;
Diagnosis, Differential;
Germinal Center;
Hodgkin Disease;
Lymphocyte Depletion;
Lymphocytes;
Lymphoma, B-Cell;
Sclerosis
- From:Korean Journal of Medicine
2011;81(5):543-553
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Recent advances in the understanding of the biology of Hodgkin lymphoma have led to a new classification. Hodgkin lymphoma is now recognized as a B-cell disorder of germinal center or post-germinal center origin. In the WHO classification, Hodgkin lymphoma consists of two categories, namely, nodular lymphocyte predominant Hodgkin lymphoma and classical Hodgkin lymphoma. Classical Hodgkin lymphoma encompasses not only nodular sclerosis, mixed cellularity, and lymphocyte depletion subtypes, but also lymphocyte-rich subtype, among which, nodular sclerosis stands out as a distinct entity. A borderline neoplasm with features intermediate between Hodgkin lymphoma and diffuse large B-cell lymphoma has also been recognized.
