Sleep Disorder Associated with Gastroesophageal Reflux Disease.
- Author:
Ju Young CHOI
1
;
Hye Kyung JUNG
;
Sun Hee ROH
;
Chung Hyun TAE
;
Seong Eun KIM
;
Ki Nam SHIM
;
Sung Ae JUNG
Author Information
1. Department of Internal Medicine, Ewha Medical Research Institute, Ewha Womans University School of Medicine, Seoul, Korea. junghk@ewha.ac.kr
- Publication Type:Original Article
- Keywords:
Insomnia;
Gastroesophageal reflux disease;
Non-erosive reflux disease;
Extra-esophageal syndrome
- MeSH:
Anxiety;
Depression;
Gastroesophageal Reflux;
Heartburn;
Humans;
Logistic Models;
Multivariate Analysis;
Prevalence;
Surveys and Questionnaires;
Sleep Initiation and Maintenance Disorders
- From:Korean Journal of Medicine
2011;81(5):602-610
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Gastroesophageal reflux disease (GERD) may contribute to the development of sleep disturbance, which may, in turn, provoke or worsen GERD. We evaluated the prevalence of GERD, non-erosive reflux disease (NERD), and extra-esophageal syndrome in subjects with self-reported sleep disturbance. METHODS: Subjects presenting for a health check-up were enrolled. Valid self-administered questionnaires provided information about reflux symptoms and sleep disturbances. We defined insomnia as self-reported sleep disturbance that occurred at least twice a week. GERD was defined as at least weekly symptoms of heartburn or acid regurgitation. Factors affecting sleep disturbance were revealed by a logistic regression analysis. RESULTS: We recruited 1,701 subjects (men 57.5%; mean age 45.0 +/- 15.0 years). The prevalence of sleep disturbance was 16.3%. GERD was reported in 14.8% of the subjects with insomnia and 7.1% of controls (p < 0.001). The prevalence of NERD was 13.7% in subjects with insomnia and 6.2% in controls (p < 0.001). The prevalence of extra-esophageal symptoms was higher in the insomniacs than controls. There was a significant correlation between the number of extra-esophageal symptoms and the frequency of sleep disturbance. Multivariate analysis showed that having GERD, NERD, extra-esophageal symptoms, and high depression and anxiety scores were predictors of sleep disturbance. CONCLUSIONS: The prevalence of GERD is higher in subjects with sleep disturbance. The number of extra-esophageal symptoms was correlated with the severity of poor sleep quality, regardless of the presence of erosive change. These findings have therapeutic implications for GERD, NERD, and extra-esophageal syndrome in patients with sleep disturbance, and future trials are warranted.
