Association of BRAF(V600E) Mutation with Poor Clinical Prognostic Factors and Ultrasonographic Findings in Cases of Papillary Thyroid Carcinoma.
10.16956/kjes.2012.12.1.16
- Author:
Hyang Suk CHOI
1
;
Kwang Min KIM
;
Joon Beom PARK
;
Keum Seok BAE
;
Seong Joon KANG
Author Information
1. Department of Surgery, Wonju College of Medicine, Yonsei University, Wonju, Korea. mdkang@yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
BRAFV600E mutation;
Clinicopathologic factors;
Ultrasonographic characteristics
- MeSH:
Diagnosis;
Gangwon-do;
Humans;
Neoplasm Metastasis;
Thyroid Gland*;
Thyroid Neoplasms*;
Thyroidectomy
- From:Korean Journal of Endocrine Surgery
2012;12(1):16-20
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study evaluated the association of the BRAF(V600E) mutation with known prognostic factors and ultrasonographic characteristics in cases of papillary thyroid carcinoma. METHODS: Subjects included 169 patients who received thyroidectomy at Wonju Christian Hospital under the diagnosis of papillary thyroid cancer from February 2010 to October 2011. RESULTS: Of the total patients who received thyroidectomy, there were 128 cases (75,7%) of BRAF(V600E) mutation. Neither age nor sex were associated with the BRAF(V600E) mutation. Tumor size, shape, margin, extrathyroidal extension, central node metastasis and lateral node metastasis were found not to be associated with the BRAF(V600E) mutation. Tumor calcification, echogenicity and vascularity were also not associated with the mutation. CONCLUSION: As debate remains about the association between the BRAF(V600E) mutation and clincopathologic factors and ultrasonographic characteristics in cases of papillary thyroid carcinoma, further study is needed.
