Comparison of Erythrocyte Traits Among European, Japanese and Korean.
- Author:
Ji Sun KWON
1
;
Sangsoo KIM
Author Information
1. Department of Bioinformatics and Life Science, Soongsil University, Seoul 156-743, Korea. sskimb@ssu.ac.kr
- Publication Type:Original Article
- Keywords:
erythrocyte;
GWAS;
hematocrit;
hemoglobin;
red blood cell
- MeSH:
Asian Continental Ancestry Group;
DNA, Intergenic;
Erythrocytes;
Genome-Wide Association Study;
Hematocrit;
Hematologic Diseases;
Hemoglobins;
Humans
- From:Genomics & Informatics
2010;8(3):159-163
- CountryRepublic of Korea
- Language:English
-
Abstract:
Erythrocyte traits are heritable and indirect indicators of blood diseases caused by erythrocyte, but their genetic factors are largely unknown. So we performed genome-wide association study in 8,842 Korean individuals to identify genetic factors influencing erythrocyte traits. We identified 40 associations for three erythrocyte traits at genome-wide significance levels (p<1x10-6). We compared these associated loci with those reported in genome-wide association studies of European and Japanese. Our findings include previously identified loci (HBS1L-MYB, TMPRSS6, USP49 and CCND3) in other studies and novel associations (MRDS1/OFCC1, CSDE1, NRAS and 8 other loci). For example, SNP rs4895440 of HBS1L-MYB intergenic region on chromosome 6q23.3 is one of the most associations influencing erythrocyte traits (p=8.33x10-27).
