An analysis of a humidifier disinfectant case from a toxicological perspective.
- Author:
Kwangsik PARK
1
Author Information
- Publication Type:Original Article
- Keywords: Humidifier disinfectant; Polyhexamethylene guanidine; Systemic toxicity
- MeSH: Chemistry; Guanidine; Humans; Humidifiers*; Lung; Lung Diseases; Methods; Polymers; Pulmonary Fibrosis
- From:Environmental Health and Toxicology 2016;31(1):e2016013-
- CountryRepublic of Korea
- Language:English
- Abstract: An analysis of patients and fatalities due to exposure to polyhexamethylene guanidine (PHMG) shows that PHMG causes mainly lung diseases such as pulmonary fibrosis. However, no research on the other organs has been conducted on this matter yet. So, an in-depth discussion on toxicological techniques is needed to determine whether or not PHMG is toxic to organs other than just the lungs. For the test of target organ toxicity by PHMG exposure, a toxicokinetic study must first be conducted. However, measurement method for PHMG injected into the body has not yet been established because it is not easy to analyze polymer PHMG, so related base studies on analytical technique for PHMG including radio-labeling chemistry must come first. Moreover, research on exposure-biomarker and effect-biomarker must also be conducted, primarily related to clinical application. Several limitations seem to be expected to apply the biomarker study to the patient because much time has passed after exposure to the humidifier disinfectant. It is why a more comprehensive toxicological researches must be introduced to the causality for the victims.
