Effect of Adenine on Clozapine-induced Neutropenia in Patients with Schizophrenia: A Preliminary Study.
10.9758/cpn.2015.13.2.157
- Author:
Ippei TAKEUCHI
1
;
Taro KISHI
;
Manako HANYA
;
Junji UNO
;
Kiyoshi FUJITA
;
Hiroyuki KAMEI
Author Information
1. Department of Psychiatry, Okehazama Hospital, Toyoake, Aichi, Japan. 134331503@ccalumni.meijo-u.ac.jp
- Publication Type:Original Article
- Keywords:
Clozapine;
Adenine;
Neutropenia;
Schizophrenia;
Side-effect
- MeSH:
Adenine*;
Clozapine;
Humans;
Japan;
Leukocyte Count;
Neutropenia*;
Retrospective Studies;
Schizophrenia*
- From:Clinical Psychopharmacology and Neuroscience
2015;13(2):157-162
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: This study examined the utility of adenine for preventing clozapine-induced neutropenia. METHODS: This retrospective study examined the effect of adenine on clozapine-induced neutropenia in patients with treatment-resistant schizophrenia and was conducted at Okehazama Hospital in Japan from July 2010 to June 2013. Adenine was available for use from June 2011 onwards. Twenty-one patients started receiving clozapine treatment from July 2010 to April 2011 (the pre-adenine adoption group), and 47 patients started receiving it from May 2011 to June 2013 (the post-adenine adoption group). The effects of adenine were assessed based on changes in the patients' leukocyte counts and the frequency of treatment discontinuation due to clozapine-induced neutropenia. RESULTS: Sixty-eight patients were treated with clozapine from July 2010 to June 2013. Of the 21 patients in the pre-adenine adoption group, 4 discontinued treatment due to clozapine-induced neutropenia, whereas only 2 of the 47 patients in the post-adenine adoption group discontinued treatment. The frequency of treatment discontinuation due to clozapine-induced neutropenia was significantly lower in post-adenine adoption group than in the pre-adenine adoption group (p=0.047). CONCLUSION: Adenine decreased the frequency of treatment discontinuation due to clozapine-induced neutropenia. Our data suggest that combined treatment with clozapine and adenine is a safe and effective strategy against treatment-resistant schizophrenia.
