The Effect of Choline Acetyltransferase Genotype on Donepezil Treatment Response in Patients with Alzheimer's Disease.
10.9758/cpn.2015.13.2.168
- Author:
Kang Uk LEE
1
;
Jung Hie LEE
;
Dong Young LEE
;
Jong Chul YOUN
;
Jeong Lan KIM
;
Seok Woo MOON
;
Bong Jo KIM
;
Seung Ho RYU
;
Moon Doo KIM
;
Chang Uk LEE
;
Nam Jin LEE
;
Sung Man CHANG
;
Young Hoon KIM
;
Do Hoon KIM
;
Hae Kook LEE
;
Jong Inn WOO
;
Ki Woong KIM
;
Jin Hyeong JHOO
Author Information
1. Department of Psychiatry, Kangwon National University School of Medicine, Chuncheon, Korea. jhoojh@kangwon.ac.kr
- Publication Type:Original Article
- Keywords:
Choline acetyltransferase;
Single nucleotide polymorphism;
Alzheimer disease;
Donepezil
- MeSH:
Alleles;
Alzheimer Disease*;
Choline O-Acetyltransferase*;
Choline*;
Depression;
Follow-Up Studies;
Genotype*;
Humans;
Polymorphism, Single Nucleotide
- From:Clinical Psychopharmacology and Neuroscience
2015;13(2):168-173
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: We examined the difference in responses to donepezil between carriers and non-carriers of the A allele at the +4 position of the choline acetyltransferase (ChAT) gene in Koreans. METHODS: Patients who met the criteria for probable Alzheimer's disease (AD) (n=199) were recruited. Among these, 145 completed the 12-week follow-up evaluation and 135 completed the 26-week scheduled course. Differences and changes in the Korean version of the mini-mental state examination (MMSE-KC) score, Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Neuropsychological Assessment Battery (CERAD-K[N]) wordlist subtest score (WSS), CERAD-K(N) total score (TS), and the Korean version of geriatric depression scale (GDS-K) score between baseline and 12 weeks or 26 weeks were assessed by the Student's t-test. RESULTS: At 12 weeks, the changes in the MMSE-KC score, CERAD-K(N) WSS, and CERAD-K(N) TS from baseline were not significant between ChAT A allele carriers and non-carriers; however, at 26 weeks, these changes were significantly larger in ChAT A allele carriers than in non-carriers (p=0.02 for MMSE-KC and p=0.03 for CERAD-K(N) WSS respectively). CONCLUSION: Our findings in this study suggested that presence of the A allele at the +4 position of ChAT might positively influence the treatment effect of donepezil in the early stages of AD in Koreans.
