The Effect of Phosphodiesterase-4-Specific Inhibitor in the Rat Model of Spinal Nerve Ligation.
10.3340/jkns.2011.50.2.109
- Author:
Sung Hoon KIM
1
;
Bit Na Ri PARK
;
Seok Won KIM
Author Information
1. Department of Rehabilitation, College of Medicine, Wonju Christian Hospital, Yonsei University, Wonju, Korea.
- Publication Type:Original Article
- Keywords:
Peripheral nerve injury;
Allodynia;
Rolipram
- MeSH:
Animals;
Burns;
Cyclic Nucleotide Phosphodiesterases, Type 4;
Hyperalgesia;
Injections, Intraperitoneal;
Ligation;
Neural Conduction;
Peripheral Nerve Injuries;
Peripheral Nervous System Diseases;
Rats;
Rolipram;
Spinal Nerves
- From:Journal of Korean Neurosurgical Society
2011;50(2):109-113
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Peripheral neuropathy is characterized by hyperalgesia, spontaneous burning pain, and allodynia. The purpose of this study was to investigate the effect of rolipram, a phosphodiesterase-4-specific inhibitor, in a segmental spinal nerve ligation model in rats. METHODS: Both the L5 and L6 spinal nerves of the left side of the rats were ligated. Phosphodiesterase-4 inhibitor (rolipram) and saline (vehicle) were administered intraperitoneally. We measured mechanical allodynia using von Frey filaments and a nerve conduction study. RESULTS: The mechanical allodynia, which began to manifest on the first day, peaked within 2 days. Multiple intraperitoneal injections of rolipram ameliorated the mechanical allodynia. Furthermore, an intraperitoneal administration of rolipram improved the development of pain behavior and nerve conduction velocity. CONCLUSION: This study suggests that the phosphodiesterase-4 inhibitor, rolipram, alleviates mechanical allodynia induced by segmental spinal nerve ligation in rats. This finding may have clinical implications.
