Alteration in Contact Hypersensitivity of Mice induced by Indomethacin Treatment.
- Author:
Seung Kyung HANN
;
Yoon Kee PARK
;
Hyung Il KIM
;
Eung Ho CHOI
- Publication Type:Original Article
- Keywords:
Contact Hypqrsensitivity;
Indomethacin
- MeSH:
Animals;
Dermatitis, Contact*;
Indomethacin*;
Mice*;
Plasma;
Prostaglandin-Endoperoxide Synthases
- From:Korean Journal of Dermatology
1990;28(3):278-282
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To study the effect of indomethacin treatment on the reactivity of contact hypersensitivity and discuss relevant mediators which could affect contact hypersensitivity, the following items were evaluated: the change in the plasma concentration of prostsglandin E following indomethacin treatment; the change of contact hypersensitivity following indomethacin treatment. The results ore summarized as follows: 1. The plasma level of prostaglandin E in indomethacin treated mice decreased. 2. The contact hypersensitivity of indomethacin treated mice was depressed. Considering the suppression of contact hyper sensitivity by indomethacin treatment, the metabolites of cyclo-oxygenase such as prostaglandin E may be the possible mediators of induction of contact hypersensitivity.
