Detection of Pre-invasive Endobronchial Tumors with D-light/Autofluorescence System.
10.3346/jkms.2006.21.2.242
- Author:
Tae Won JANG
1
;
Chul Ho OAK
;
Bong Kwon CHUN
;
Mann Hong JUNG
Author Information
1. Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea. jangtw@ns.kosinmed.or.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Bronchoscopes;
Fluorescence;
Bronchoscopy;
Lung Neoplasms
- MeSH:
Precancerous Conditions/diagnosis/pathology;
Middle Aged;
Metaplasia;
Male;
Lung Neoplasms/diagnosis/pathology;
Hyperplasia;
Humans;
Fluorescence;
Female;
Carcinoma, Squamous Cell/diagnosis/pathology;
Carcinoma in Situ/diagnosis/pathology;
Bronchoscopy/*methods;
Bronchial Neoplasms/*diagnosis/pathology;
Bronchi/pathology;
Aged, 80 and over;
Aged;
Adult
- From:Journal of Korean Medical Science
2006;21(2):242-246
- CountryRepublic of Korea
- Language:English
-
Abstract:
Autofluorescence bronchoscopy (AFB) is one of the newly developed diagnostic tools to detect the pre-cancerous lesions in the bronchial tissue. The utility of DLight/AFB in the detection of pre-cancerous lesions was compared to the standard white light bronchoscopy (WLB). In 113 patients (male 106, female 7), who visited hospital for evaluation of lung cancer, WLB and AFB were done and 364 biopsy specimens were obtained from November 2001 to August 2002. The bronchoscopic findings on WLB and AFB were compared to the pathological findings. The pathologic diagnoses of the specimens were as follows: normal in 96; hyperplasia in 69; metaplasia in 32; mild dysplasia in 13, moderate dysplasia in 6, severe dysplasia in 4; carcinoma in situ in 6; invasive carcinoma in 57. The relative sensitivity of adjunctive AFB to WLB vs. WLB alone was 1.5 in moderate dysplasia or worse lesions, and 3.2 in intraepithelial neoplasia. The specificity of adjunctive AFB and WLB alone were 0.91 and 0.5, respectively. The adjunctive AFB to the standard WLB increased the detection rate of the localized pre-invasive lesions. However, there was high rate of false positive in AFB.
