Risk Factors for Primary Multidrug Resistant Tuberculosis.
10.4046/trd.2005.59.6.600
- Author:
Jinhong MIN
1
;
Keeho PARK
;
Suhee WHANG
;
Jinhee KIM
Author Information
1. National Masan Hospital, Masan, Korea.
- Publication Type:Original Article
- Keywords:
Drug resistance;
Mycobacterium tuberculosis;
Risk factor
- MeSH:
Case-Control Studies;
Diabetes Mellitus;
Drug Resistance;
Humans;
Isoniazid;
Logistic Models;
Mycobacterium tuberculosis;
Odds Ratio;
Prevalence;
Prospective Studies;
Rifampin;
Risk Factors*;
Tuberculosis*;
Tuberculosis, Multidrug-Resistant
- From:Tuberculosis and Respiratory Diseases
2005;59(6):600-605
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Primary multidrug-resistant tuberculosis is defined as Mycobacterium tuberculosis isolates that are resistant to at least isoniazid and rifampin in never-been-treated tuberculosis patients, and this malady is caused by the transmission of a resistant strain from one patient, who is infected with a resistant Mycobacterium tuberculosis strain, to another patient. The prevalence of primary multidrug-resistant tuberculosis could be a good indicator of the performance of tuberculosis control programs in recent years. We conducted a case-control study to identify the risk factors for primary multidrug-resistant tuberculosis. METHODS: From January 1, 2001 to, June 30, 2003, by conducting prospective laboratory-based surveillance, we identified 29 hospitalized patients with P-MDRTB and these patients constituted a case group in this study. The controls were represented by all the patients with culture-confirmed drug susceptible tuberculosis who were admitted to National Masan Hospital during the same study period. The odds ratios for the patients with primary multidrug-resistant tuberculosis, as compared with those of the patients with drug susceptible tuberculosis, were calculated for each categorical variable with 95% confidence intervals. RESULTS: Multivariate logistic regression showed that the presence of diabetes mellitus (odds ratio 2.68; 95% confidence interval, 1.05-6.86) was independently associated with having primary multidrug-resistant tuberculosis. CONCLUSION: This study has shown that diabetes mellitus might be one of the risk factors for primary multidrug-resistant tuberculosis.
