Recurrence and Its Impact on the Health-related Quality of Life in Patients with Gastroesophageal Reflux Disease: A Prospective Follow-up Analysis.
- Author:
Yang Won MIN
1
;
Yong Woon SHIN
;
Gab Jin CHEON
;
Kyung Sik PARK
;
Hyun Soo KIM
;
Chong Il SOHN
;
Tae Nyeun KIM
;
Hyeung Cheol MOON
;
Poong Lyul RHEE
Author Information
- Publication Type:Multicenter Study ; Original Article
- Keywords: Gastroesophageal reflux; Quality of life; Recurrence; Therapy
- MeSH: Asian Continental Ancestry Group; Esophagitis; Follow-Up Studies*; Gastroesophageal Reflux*; Heartburn; Humans; Multivariate Analysis; Prospective Studies*; Quality of Life*; Recurrence*; Risk Factors; Treatment Outcome
- From:Journal of Neurogastroenterology and Motility 2016;22(1):86-93
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Limited data exist on the outcome of gastroesophageal reflux disease (GERD) treatment and its impact on the health-related quality of life (HRQoL) in the Asian population. This study aims to evaluate the treatment outcomes, to investigate the factors associated with recurrence, and to evaluate the impact of the treatment outcome on the HRQoL in a Korean GERD population. METHODS: This was a prospective, multicenter study involving a total of 824 GERD patients. The response to treatment was assessed at week 4 (or week 8 for the patients who did not achieve complete resolution [CR] at week 4). The EQ-5D questionnaire was used at baseline, end of treatment, and first recurrence to assess the HRQoL. To assess GERD symptoms, contact of patients by phone at 1, 6, and 12 months following treatment was carried out. RESULTS: CR was achieved in 65.6% and recurrence was observed in 47.8% following treatment. CR and recurrence rates did not differ by the presence of esophagitis. Multivariate analysis revealed that acid regurgitation (odds ratio 2.249; 95% confidence interval 1.293-3.912; P = 0.004) and both acid regurgitation and heartburn (odds ratio 2.330; 95% confidence interval 1.392-3.901; P = 0.001) were independent risk factors for GERD recurrence. EQ-5D scores were more improved in patients with CR than in those without CR, and worsened more during follow-up in patients with recurrence than in those without recurrence. CONCLUSIONS: We should achieve complete symptom relief and attempt to prevent recurrence in GERD patients to improve their HRQoL.
