Comparison of various noninvasive serum markers of liver fibrosis in chronic viral liver disease.
10.3350/kjhep.2009.15.4.454
- Author:
Sun Min KIM
1
;
Joo Hyun SOHN
;
Tae Yeob KIM
;
Young Wook ROH
;
Chang Soo EUN
;
Yong Cheol JEON
;
Dong Soo HAN
;
Young Ha OH
Author Information
1. Department of Internal Medicine, Hanyang University College of Medicine, Guri, Korea. sonjh@hanyang.ac.kr
- Publication Type:Original Article ; Comparative Study ; English Abstract
- Keywords:
Chronic viral liver disease;
Liver fibrosis;
Noninvasive serum markers
- MeSH:
Adult;
Alanine Transaminase/blood;
Area Under Curve;
Aspartate Aminotransferases/blood;
Biological Markers/blood;
Collagen Type IV;
Female;
Hepatitis B, Chronic/*complications;
Hepatitis C, Chronic/*complications;
Humans;
Hyaluronic Acid/blood;
Liver Cirrhosis/*diagnosis/virology;
Male;
Middle Aged;
Platelet Count;
Predictive Value of Tests;
Severity of Illness Index
- From:The Korean Journal of Hepatology
2009;15(4):454-463
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: The aim of this study was to determine the clinical performances of noninvasive serum markers for the prediction of liver fibrosis in chronic viral liver diseases. METHODS: We analyzed a total of 225 patients with chronic viral liver diseases (180 with hepatitis B virus, 43 with hepatitis C virus, and 2 with hepatitis B+C virus) who underwent a liver biopsy procedure at the Hanyang University Guri Hospital between March 2002 and February 2007. Serum was also obtained at the time of liver biopsy. Liver fibrosis was staged according to the scoring system proposed by the Korean Study Group for the Pathology of Digestive Diseases. Various noninvasive serum markers were evaluated, including the aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio (AAR), age-platelet (AP) index, AST/platelet ratio index (APRI), cirrhosis discriminant score (CDS), platelet count, hyaluronic acid (HA), and type IV collagen. RESULTS: There were 17, 40, 61, 74, and 33 patients at stages F0, F1, F2, F3, and F4, respectively. The overall diagnostic accuracies of each marker, as determined by the area under receiver operating characteristics curves, were APRI=0.822, CDS=0.776, platelet count=0.773, AP index=0.756, HA=0.749, type IV collagen=0.718, and AAR=0.642 for predicting significant fibrosis (> or =F2); and CDS=0.835, platelet count=0.795, AP index=0.794, HA=0.766, AAR=0.711, type IV collagen=0.697, and APRI=0.691 for predicting extensive fibrosis (> or =F3). CONCLUSIONS: All noninvasive serum markers evaluated in this study were useful for predicting significant or extensive liver fibrosis in chronic viral liver diseases. In particular, APRI was most useful for the prediction of significant fibrosis, and CDS was most useful for the prediction of extensive fibrosis.
