Comparative Analysis of Vascular Endothelial Growth Factor-A, C, D Expression in Colorectal Cancer with Liver Metastasis.
10.4174/jkss.2009.76.5.307
- Author:
Kwang Sik CHUN
1
;
Kyung Ha LEE
;
In Sang SONG
;
Ji Yeon KIM
;
Je Ryong KIM
;
Moon Sang AHN
;
Sang Il LEE
;
Jong Hyun PARK
;
Song E CHOI
;
Dae Young KANG
;
Kyu Sang SONG
Author Information
1. Department of Surgery, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon, Korea. songis@cnuh.co.kr
- Publication Type:Original Article
- Keywords:
VEGF-A;
VEGF-C;
VEGF-D;
Colorectal cancer;
Liver metastasis
- MeSH:
Colorectal Neoplasms;
Cytokines;
Humans;
Liver;
Lymph Nodes;
Neoplasm Metastasis;
Recurrence;
Vascular Endothelial Growth Factor A;
Vascular Endothelial Growth Factor C;
Vascular Endothelial Growth Factor D
- From:Journal of the Korean Surgical Society
2009;76(5):307-315
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We aimed to investigate the correlations between expressions of angiogenic cytokines VEGF-A, C, D of primary colorectal cancer and liver metastasis. METHODS: We examined paraffin-embedded primary colorectal cancer tissue from 45 patients who had liver resection due to colorectal liver metastasis (metastasis group) and 37 patients who had surgical resection due to colorectal cancer only (control group). In the control group, local recurrence and distant metastasis had not occurred. Immunohistochemical staining for VEGF-A, C and D was performed. We analysed the correlations between expression of VEGF-A, C and D in primary colorectal cancer tissues and clinicopathologic parameters. RESULTS: VEGF-A expressions of primary colorectal carcinoma were not different between the two groups. VEGF-C was more frequently expressed in the metastasis group (P=0.008) but VEGF-D was more expressed in the control group (P=0.003). Patients with VEGF-C negative and VEGF-D positive expression were predominant in the control group (P=0.020). Tumor location, T stage, lymph node metastasis and tumor differentiation were not related with the expressions of VEGF-A, C, D but only preoperative CEA was positively correlated with VEGF-A and C expression. CONCLUSION: Expressions of VEGF-C in primary tumor were more frequent in metastatic colorectal cancer and expressions of VEGF-D were more frequent in nonmetastatic colorectal cancer. More large-scale prospective studies for VEGF-C and D expression in colorectal cancer are necessary.
